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ART ongoing research


Several research projects are ongoing in cooperation with the eye clinic at the University Hospital of Umeå. A cross linking study recently began to evaluate possibility to detect biomechanical properties with the ART sensor technology. A two year follow-up of LASEK treated eyes was completed in the end of 2010, showing that the sensor perform on reshaped corneas.

 

Research

Background information about our research and our products

BioResonator is based on the patents that resulted from joint research by Professor Sadao Omata and co-workers in Japan, and professor Olof Lindahl and co-workers at Umeå University in Sweden. BioResonators core technology is a resonating sensor made out of piezoelectric ceramics.
The R&D team has been, and still are, an active part of the development of the resonance technology, including the scientific verification of the technology and part of product development within the field of IOP-measurement.
The Research group has published more than one hundred scientific papers.

BioResonator have a wide range of experience in:
  • Basic research
  • Applied research
  • Product development
  • Building prototypes
  • Industrial productification
  • Commercialisation of medical devices

Future Applications


Corneal Biomechanics

Corneal Biomechanics

Bioresonator´s Applanation resonance tonometer samples contact force and contact area continuously during the measurement of intraocular pressure. Force and contact area combined with a controlled sensor velocity offers a unique possibility to evaluate the biomechanics of the cornea. Several project are ongoing in close collaboration with the University Hospital of Umeå.


Prostate cancer

Prostate cancer

There is at present no measurement method that can accurately and non-invasively detect prostate cancer. The research team in Umeå have demonstrated that there is a close correlation between the frequency shift of the resonator sensor and the tissue composition of in vitro prostate samples from human prostate. The findings are very promising for the development of a resonator sensor for objective rectal palpation of human prostate as a means of diagnosing cancer. Intense research collaboration between Umeå University and Luleå University are on-going.


Brest Checker

Brest Checker

Breast Self-Exam Detection of breast cancer and the regular monitoring of the response to neo-adjuvant chemotherapy are important issues to woman. To address this need, Professor Omata and his research team developed a probe for examination of the stiffness of the breast using haptic sensor technology. The team has indicated that the Breast-Checker can tell the divergence between normal tissue and lumps that might indicate breast cancer. The Breast-Checker can be developed to make it possible for women to check the status in their breasts by themselves.


Oedema level tools

Oedema level tools

Oedema, i.e. abnormal accumulation of interstitial fluid in tissue, is a common sign of disease. It can also be a sign of physiological dysfunction or trauma. There are currently few instruments that can measure the level of oedema in an objective and non-invasive way. However, the Umeå research group has published findings showing that the resonator sensor has the potential to make reliable measurements




Selected references
  1. Hallberg, P., Eklund, A., Backlund, T. & Linden, C. (2007). Clinical Evaluation of Applanation Resonance Tonometry: A Comparison With Goldmann Applanation Tonometry . J Glaucoma 16, 88-93 .
  2. Hallberg, P., Eklund, A., Santala, K., Koskela, T., Lindahl, O. & Linden, C. (2006). Underestimation of intraocular pressure after photorefractive keratectomy: a biomechanical analysis. Med Biol Eng Comput 44, 609-18 .
  3. Hallberg, P., Linden, C., Lindahl, O. A., Backlund, T. & Eklund, A. (2004). Applanation resonance tonometry for intraocular pressure in humans. Physiol Meas 25, 1053-65 .
  4. Eklund, A., Hallberg, P., Linden, C. & Lindahl, O. A. (2003). An applanation resonator sensor for measuring intraocular pressure using combined continuous force and area measurement. Investigative Ophthalmology & Visual Science 44, 3017-24 .
  5. Eklund, A., Linden, C., Backlund, T., Andersson, B. M. & Lindahl, O. A. (2003). Evaluation of applanation resonator sensors for intra-ocular pressure measurement: results from clinical and in vitro studies. Medical & Biological Engineering & Computing 41, 190-7 .
  6. Eklund, A., Backlund, T. & Lindahl, O. A. (2000). A resonator sensor for measurement of intraocular pressure--evaluation in an in vitro pig-eye model. Physiological Measurement 21, 355-67 .
  7. Eklund, A., Bergh, A. & Lindahl, O. A. (1999). A catheter tactile sensor for measuring hardness of soft tissue: measurement in a silicone model and in an in vitro human prostate model. Medical and Biological Engineering and Computing 37, 618-24.
 
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BioResonator AB
Tvistevägen 47A
SE-901 87 Umeå
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Tel +56 (0)90 18 46 20
Fax +46 (0)90 18 46 27
Mail info@bioresonator.com